C₁₈H₁₈ClN₇O₂S

Base Information

Chemical Name:C₁₈H₁₈ClN₇O₂S
CAS No.:1377551-42-2
Molecular Formula:C₁₈H₁₈ClN₇O₂S
Molecular Weight:431.906
Hs Code.:

C<sub>18</sub>H<sub>18</sub>ClN<sub>7</sub>O<sub>2</sub>S

Synonyms:C₁₈H₁₈ClN₇O₂S

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Chemical Property of C₁₈H₁₈ClN₇O₂S

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Technology Process of C₁₈H₁₈ClN₇O₂S

There total 6 articles about C₁₈H₁₈ClN₇O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 4858-85-9
2,3-dichloropyrazine

: 5-(3-(piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

: 1377551-42-2
C₁₈H₁₈ClN₇O₂S

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 120 ℃;
DOI:10.1021/jm300403a

Reference yield:

: 1033743-83-7
C₂₁H₃₃BN₂O₆S

: 1377551-42-2
C₁₈H₁₈ClN₇O₂S

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

2: hydrogenchloride / 1,4-dioxane; water / 20 °C

3: potassium carbonate / N,N-dimethyl acetamide / 120 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a

Reference yield:

: 2905-24-0
3-Bromobenzenesulfonyl chloride

: 1377551-42-2
C₁₈H₁₈ClN₇O₂S

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 2 h / 90 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

4: hydrogenchloride / 1,4-dioxane; water / 20 °C

5: potassium carbonate / N,N-dimethyl acetamide / 120 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl acetamide; water; 2: Suzuki-Miyaura cross-coupling / 3: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a