(R)-3-AMINO-1-BENZYLPYRROLIDINE DIHYDROCHLORIDE

Base Information

• Chemical Name: (R)-3-AMINO-1-BENZYLPYRROLIDINE DIHYDROCHLORIDE
• CAS No.: 215947-36-7
• Molecular Formula: C₁₁H₁₆N₂*(x)ClH
• Molecular Weight: 249.18
• Hs Code.: 2933990090
• Mol file: 215947-36-7.mol

Synonyms:3-Pyrrolidinamine,1-(phenylmethyl)-, dihydrochloride, (3R)- (9CI);

Chemical Property of (R)-3-AMINO-1-BENZYLPYRROLIDINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 29.26000
• LogP: 3.46180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(R)-1-Benzylpyrrolidin-3-aminedihydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-AMINO-1-BENZYLPYRROLIDINE DIHYDROCHLORIDE

There total 1 articles about (R)-3-AMINO-1-BENZYLPYRROLIDINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-3-aminopyrrolidine (18471-40-4,60652-45-1,114715-38-7,114715-39-8) → (R)-1-benzyl-3-aminopyrrolidine monohydrochloride (608090-19-3,131852-54-5,215947-36-7,368429-76-9)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; Product distribution / selectivity;

Reference yield: 0.65%

di-tert-butyl dicarbonate (24424-99-5) + (3R)-(-)-1-benzyl-3-aminopyrrolidine hydrochloride (131852-54-5,215947-36-7,368429-76-9) → (3R)-1-benzyl-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine (131878-23-4)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

(3R)-(-)-1-benzyl-3-aminopyrrolidine hydrochloride (131852-54-5,215947-36-7,368429-76-9) → (3R)-1-benzyl-N-methylpyrrolidin-3-amine (144043-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water; acetonitrile

2: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

With lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile;

upstream raw materials:

1-Benzyl-3-aminopyrrolidine

Downstream raw materials:

(3R)-1-benzyl-N-methylpyrrolidin-3-amine

(3R)-1-benzyl-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine

Refernces