(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Base Information

• Chemical Name: (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one
• CAS No.: 415927-43-4
• Molecular Formula: C₁₆H₁₈N₂O₃
• Molecular Weight: 286.331
• Mol file: 415927-43-4.mol

Synonyms:(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Chemical Property of (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

There total 4 articles about (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

6-(3,4-dimethoxy-benzoyl)-cyclohex-3-enecarboxylic acid (439660-85-2) → (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one (415927-43-4)

Guidance literature:

With hydrazine; In ethanol; for 4h; Product distribution / selectivity; Heating / reflux;

Reference yield:

cis-(+/-)-6-(3,4-dimethoxybenzoyl)cyclohex-3-enecarboxylic acid → (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one (415927-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: resolution with (R)-(+)-α-methylbenzylamine

2: hydrazine monohydrate; AcOH / ethanol / Heating

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1021/jm0110338

Reference yield:

cis-(-)-6-(3,4-dimethoxybenzoyl)cyclohex-3-enecarboxylic acid → (cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one (415927-43-4) + (4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; Title compound not separated from byproducts.; Heating;

DOI:10.1021/jm0110338

upstream raw materials:

6-(3,4-dimethoxy-benzoyl)-cyclohex-3-enecarboxylic acid