(2-bromothiophen-3-yl)methanamine Hydrochloride

Base Information

• Chemical Name: (2-bromothiophen-3-yl)methanamine Hydrochloride
• CAS No.: 157664-47-6
• Molecular Formula: C₅H₆BrNS
• Molecular Weight: 192.079
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10384181
• Mol file: 157664-47-6.mol

Synonyms:(2-bromothiophen-3-yl)methanamine Hydrochloride;886460-60-2;C-(2-BROMO-THIOPHEN-3-YL)-METHYLAMINE HYDROCHLORIDE;(2-BROMO-3-THIENYL)METHYLAMINE HYDROCHLORIDE;(2-bromothiophen-3-yl)methanamine;hydrochloride;3-(Aminomethyl)-2-bromothiophene hydrochloride;DTXSID10384181;3-(Aminomethyl)-2-bromothiophene;MFCD04971979;SB39608;MS-22117;(2-bromothiophen-3-yl)methanamineHydrochloride;EN300-203275;1-(2-BROMOTHIOPHEN-3-YL)METHANAMINE HYDROCHLORIDE

Chemical Property of (2-bromothiophen-3-yl)methanamine Hydrochloride

Chemical Property:

• Vapor Pressure: 0.03mmHg at 25°C
• Melting Point: 199 °C
• Refractive Index: 1.6100
• Boiling Point: 244.7 °C at 760 mmHg
• Flash Point: 101.8 °C
• PSA: 54.26000
• Density: 1.669 g/cm³
• LogP: 3.47160
• Sensitive.: Air Sensitive
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 226.91711
• Heavy Atom Count: 9
• Complexity: 78.8

Purity/Quality:

97% ^*data from raw suppliers

(2-Bromothiophen-3-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R34:Causes burns.
• Hazard Codes: Xi,C,T
• Statements: 36/37/38-34-20/21/22-41-37/38-25
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1CN)Br.Cl

Technology Process of (2-bromothiophen-3-yl)methanamine Hydrochloride

There total 3 articles about (2-bromothiophen-3-yl)methanamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(2-Bromo-thiophen-3-ylmethyl)-isoindole-1,3-dione (157664-45-4) → (2-bromothiophen-3-yl)methylamine (157664-47-6)

Guidance literature:

With hydrazine hydrate; In methanol; 1 h, room temperature, reflux, 10 min;

Reference yield:

2-bromo-3-methylthiophene (14282-76-9) → (2-bromothiophen-3-yl)methylamine (157664-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / NBS, (PhCO)2O₂ / CCl₄ / 3 h / Heating

2: 79 percent / dimethylformamide / room temperature, 90 min, 45 deg C, 90 min

3: 55 percent / N₂H₄*H₂O / methanol / 1 h, room temperature, reflux, 10 min

With N-Bromosuccinimide; hydrazine hydrate; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

2-bromo-3-(bromomethyl)thiophene (40032-76-6) → (2-bromothiophen-3-yl)methylamine (157664-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / dimethylformamide / room temperature, 90 min, 45 deg C, 90 min

2: 55 percent / N₂H₄*H₂O / methanol / 1 h, room temperature, reflux, 10 min

With hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-(2-Bromo-thiophen-3-ylmethyl)-isoindole-1,3-dione

2-bromo-3-methylthiophene

2-bromo-3-(bromomethyl)thiophene

Downstream raw materials:

N-(2-Phenyl-thiophen-3-ylmethyl)-benzamide

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