dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride

Base Information

• Chemical Name: dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride
• CAS No.: 946129-76-6
• Molecular Formula: C₂₂H₂₅ClN₄O₆S*ClH
• Molecular Weight: 545.444

Synonyms:dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride

Chemical Property of dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride

Chemical Property:

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Technology Process of dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride

There total 7 articles about dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethylcarbamic acid 3-{N-[2-(tert-butoxycarbonylamino)ethyl]sulfamoylamino}benzyl-6-chloro-4-methyl-2-oxo-2H-chromen-7-yl ester → dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride (946129-76-6)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 40 ℃; for 2h;

DOI:10.1016/j.bmcl.2013.10.001

Reference yield:

4-Chlororesorcinol (95-88-5) → dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride (946129-76-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid / water / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: tin(II) chloride dihdyrate / ethyl acetate / 7 h / 80 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 40 °C

With pyridine; hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; water; sodium hydride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 1.1: |Pechmann Condensation;

DOI:10.1016/j.bmcl.2013.10.001

Reference yield:

2-(3-nitrobenzyl)-3-oxo-butyric acid ethyl ester (393812-70-9) → dimethylcarbamic acid 3-(3-(N-(2-aminoethyl)sulfamoyl)aminobenzyl)-6-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester hydrochloride (946129-76-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid / water / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: tin(II) chloride dihdyrate / ethyl acetate / 7 h / 80 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 40 °C

With pyridine; hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; water; sodium hydride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 1.1: |Pechmann Condensation;

DOI:10.1016/j.bmcl.2013.10.001

upstream raw materials:

4-Chlororesorcinol

2-(3-nitrobenzyl)-3-oxo-butyric acid ethyl ester

3-(3-nitrobenzyl)-7-hydroxy-4-methyl-6-chloro-2-oxo-2H-1-benzopyran

dimethylcarbamic acid 2-oxo-2H-3-(3-nitrobenzyl)-4-methyl-6-chloro-1-benzopyran-7-yl ester

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