3-CHLORO-4-HYDROXYPYRIDINE

Base Information

• Chemical Name: 3-CHLORO-4-HYDROXYPYRIDINE
• CAS No.: 89284-20-8
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.546
• Hs Code.: 2933399090
• European Community (EC) Number: 812-831-3
• DSSTox Substance ID: DTXSID30376583
• Nikkaji Number: J3.074.251F
• Wikidata: Q72451978
• Mol file: 89284-20-8.mol

Synonyms:3-Chloropyridin-4-ol;

Chemical Property of 3-CHLORO-4-HYDROXYPYRIDINE

Chemical Property:

• Vapor Pressure: 0.0894mmHg at 25°C
• Melting Point: 204-205℃
• Refractive Index: 1.569
• Boiling Point: 224.8 °C at 760 mmHg
• PKA: 3.77±0.18(Predicted)
• Flash Point: 89.8 °C
• PSA: 33.12000
• Density: 1.35 g/cm³
• LogP: 1.44060
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 128.9981414
• Heavy Atom Count: 8
• Complexity: 171

Purity/Quality:

97% ^*data from raw suppliers

3-Chloropyridin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC=C(C1=O)Cl

Technology Process of 3-CHLORO-4-HYDROXYPYRIDINE

There total 3 articles about 3-CHLORO-4-HYDROXYPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

3,3,5-trichloropiperidin-4-one → 3-chloro-4-hydroxypyridine (89284-20-8)

Guidance literature:

With sodium hydroxide; In methanol; at 40 - 45 ℃; for 2h;

Reference yield: 83.0%

pyridin-4-ol (626-64-2,157061-69-3) → 3,5-dichloro-4-hydroxypyridine (17228-71-6) + 3-chloro-4-hydroxypyridine (89284-20-8)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 25 - 75 ℃; for 1h;

DOI:10.1055/s-0031-1289732

Reference yield:

→ 3-chloro-4-hydroxypyridine (89284-20-8)

Guidance literature:

3-Chlor-4-nitro-pyridin, Ba(OH)2 in sd. W.;

upstream raw materials:

pyridin-4-ol

Downstream raw materials:

3-Chlor-4-methoxy-pyridin

3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridin-4(1H)-one

3-chloro-1-[3-(trifluoromethyl)phenyl]pyridin-4(1H)-one