ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate
• CAS No.: 1018830-98-2
• Molecular Formula: C₁₄H₁₂F₃NO₂S
• Molecular Weight: 315.316
• Mol file: 1018830-98-2.mol

Synonyms:ethyl 2-amino-4-(3-(trifluoromethyl)phenyl)thiophene-3-carboxylate

Chemical Property of ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Ethyl2-amino-4-(3-(trifluoromethyl)phenyl)thiophene-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate

There total 2 articles about ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 2-cyanoacetate (105-56-6) + 3'-(trifluoromethyl)acetophenone (349-76-8) → ethyl 2-amino-4-(3-(trifluoromethyl)phenyl)thiophene-3-carboxylate (1018830-98-2)

Guidance literature:

ethyl 2-cyanoacetate; 3'-(trifluoromethyl)acetophenone; With ammonium acetate; acetic acid; In toluene; Dean-Stark; Reflux;

With sulfur; diethylamine; In ethanol; at 50 ℃; for 3h;

DOI:10.1016/j.bmcl.2013.03.019

Reference yield:

C14H12F3NO2 (1018831-14-5) → ethyl 2-amino-4-(3-(trifluoromethyl)phenyl)thiophene-3-carboxylate (1018830-98-2)

Guidance literature:

With sulfur; diethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2007.10.065

Reference yield: 45.0%

ethyl 2-amino-4-(3-(trifluoromethyl)phenyl)thiophene-3-carboxylate (1018830-98-2) + di-tert-butyl dicarbonate (24424-99-5) → C19H20F3NO4S (1018831-17-8)

Guidance literature:

With dmap; In 1,4-dioxane; at 70 - 80 ℃; for 2h;

DOI:10.1016/j.bmc.2007.10.065

upstream raw materials:

C₁₄H₁₂F₃NO₂

ethyl 2-cyanoacetate

3'-(trifluoromethyl)acetophenone

Downstream raw materials:

C₁₉H₂₀F₃NO₄S

4-(3-(trifluoromethyl)phenyl)thiophen-2-amine

2-(4-(ethylsulfonyl)phenyl)-N-(4-(3-(trifluoromethyl)phenyl)thiophen-2-yl)acetamide

N-(5-(2-chlorobenzoyl)-4-(3-(trifluoromethyl)phenyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)-phenyl)acetamide

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