4-Amino-5-chloronicotinic acid

Base Information

• Chemical Name: 4-Amino-5-chloronicotinic acid
• CAS No.: 52834-09-0
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.571
• Hs Code.: 2933399090
• Mol file: 52834-09-0.mol

Synonyms:4-Amino-5-chloronicotinicacid;

Chemical Property of 4-Amino-5-chloronicotinic acid

Chemical Property:

• Vapor Pressure: 3.54E-06mmHg at 25°C
• Refractive Index: 1.66
• Boiling Point: 371.5 °C at 760 mmHg
• PKA: 2.57±0.10(Predicted)
• Flash Point: 178.5 °C
• PSA: 76.21000
• Density: 1.577 g/cm³
• LogP: 1.59660
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-Amino-5-chloro-nicotinicacid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-5-chloronicotinic acid

There total 8 articles about 4-Amino-5-chloronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butoxycarbonylamino-5-chloro-nicotinic acid (1073182-72-5) → 4-amino-5-chloronicotinic acid (52834-09-0)

Guidance literature:

4-tert-butoxycarbonylamino-5-chloro-nicotinic acid; With hydrogenchloride; water; In methanol; for 1.5h; Heating / reflux;

With sodium hydroxide; water; at 20 ℃; pH=~ 12;

With hydrogenchloride; water; pH=~ 2;

Reference yield:

methyl 3,5,5-trichloropiperidin-4-one-3-carboxylate → 4-amino-5-chloronicotinic acid (52834-09-0)

Guidance literature:

methyl 3,5,5-trichloropiperidin-4-one-3-carboxylate; With ammonium hydroxide; In methanol; at 40 - 45 ℃; for 4h;

With water; sodium hydroxide; In methanol; at 20 - 35 ℃; for 2h;

Reference yield:

methyl 3,5,5-trichloropiperidin-4-one-3-carboxylate → 4-amino-5-chloronicotinic acid (52834-09-0) + 4-hydroxy-5-chloronicotinic acid

Guidance literature:

methyl 3,5,5-trichloropiperidin-4-one-3-carboxylate; With ammonium hydroxide; In methanol; at 40 - 45 ℃; for 4h;

With water; sodium hydroxide; In methanol; at 20 - 35 ℃; for 2h; Overall yield = 72.6 percent;

upstream raw materials:

4-aminonicotinic acid

4-tert-butoxycarbonylamino-5-chloro-nicotinic acid

methyl 4-oxonipecotate

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 52834-09-0 4-Amino-5-chloronicotinic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send