ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate

Base Information

Chemical Name:ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate
CAS No.:184680-78-2
Molecular Formula:C₁₅H₁₇ClFNO₃
Molecular Weight:313.756
Hs Code.:

Synonyms:ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate

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Chemical Property of ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate

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Technology Process of ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate

There total 3 articles about ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 1058721-62-2
2-chloro-4-fluoro-3-methylbenzoyl chloride

: 184680-78-2
ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate

Guidance literature:: With triethylamine; In toluene; at 90 ℃; for 2h; Yield given;
DOI:10.1021/jm960414w

Reference yield:

: 173315-54-3
2-chloro-4-fluoro-3-methylbenzoic acid

: 184680-78-2
ethyl 2-chloro-α-[(dimethylamino)methylene]-4-fluoro-3-methyl-β-oxo-benzenepropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: Et₃N / toluene / 2 h / 90 °C

With thionyl chloride; triethylamine; In toluene;
DOI:10.1021/jm960414w