N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

Base Information

Chemical Name:N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine
CAS No.:368870-26-2
Molecular Formula:C₄₂H₄₇N₅O₈
Molecular Weight:749.864
Hs Code.:

Synonyms:N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

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Technology Process of N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

There total 5 articles about N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 368870-25-1
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

: 368870-26-2
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja010756d

Reference yield:

: 132342-52-0
((3aR,4R,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 368870-26-2
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / K₂CO₃ / methanol / 4 h / 20 °C

2: 71 percent / pyridine / 1.5 h / 20 °C

3: 100 percent / TBAF; AcOH / tetrahydrofuran / 1 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ja010756d

Reference yield:

: 368870-20-6
5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile

: 368870-26-2
N-1-[(1R,2S,3R,4R)-2,3-(isopropylidenedioxy)-4-[(4-monomethoxytrityl)oxymethyl]cyclopentyl]-2',3'-O-isopropylideneadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / K₂CO₃ / methanol / 4 h / 20 °C

2: 71 percent / pyridine / 1.5 h / 20 °C

3: 100 percent / TBAF; AcOH / tetrahydrofuran / 1 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ja010756d