<1S-(1R,2S,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Base Information

Chemical Name:<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide
CAS No.:135704-12-0
Molecular Formula:C₃₆H₅₃Cl₃N₆O₉S₂
Molecular Weight:884.343
Hs Code.:

<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Synonyms:<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Suppliers and Price of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

There total 6 articles about <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: {4-[(S)-2-Amino-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester; hydrochloride

: 135704-12-0
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00092a006

Reference yield:

: 122621-77-6
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 135704-12-0
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

2: 92 percent / HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

3: 38 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006

Reference yield:

: 135704-30-2
(S)-3-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester

: 135704-12-0
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / DMAP / CH₂Cl₂ / 4 h / -20 °C

2: 84 percent / aq. KOH / methanol / 3.5 h / Ambient temperature

3: 73 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

4: 92 percent / HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

5: 38 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

With hydrogenchloride; dmap; potassium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006