(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

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Chemical Name:(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine
CAS No.:873920-44-6
Molecular Formula:C₂₁H₂₆N₂O₅S
Molecular Weight:418.514
Hs Code.:

Synonyms:(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

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Chemical Property of (3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

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Technology Process of (3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

There total 3 articles about (3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 873920-41-3
(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[(4RS)-4-(ethoxycarbonyl)-2-thiazolin-2-yl]isoxazolidine

: 873920-44-6
(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

Guidance literature:: With manganese(IV) oxide; In benzene; for 12h; Heating;
DOI:10.1016/j.tetasy.2005.11.004

Reference yield:

: 873920-36-6
(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-cyanoisoxazolidine

: 873920-44-6
(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / triethylamine / 3 h / 20 °C

2: 90 percent / MnO₂ / benzene / 12 h / Heating

With manganese(IV) oxide; triethylamine; In benzene;
DOI:10.1016/j.tetasy.2005.11.004

Reference yield:

: 91190-38-4,111058-38-9,1165677-00-8
N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone

: 873920-44-6
(3S,5R)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-[4-(ethoxycarbonyl)-2-thiazolyl]isoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / 4 h / Heating

2: 70 percent / triethylamine / 3 h / 20 °C

3: 90 percent / MnO₂ / benzene / 12 h / Heating

With manganese(IV) oxide; triethylamine; In benzene;
DOI:10.1016/j.tetasy.2005.11.004