ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate

Base Information

• Chemical Name: ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate
• CAS No.: 200726-99-4
• Molecular Formula: C₂₅H₂₆O₇
• Molecular Weight: 438.477

Synonyms:ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate

Chemical Property of ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate

Chemical Property:

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Technology Process of ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate

There total 3 articles about ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

ethyl 4-hydroxy-8-methyl-2-oxo-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate (200727-00-0) + benzyl alcohol (100-51-6,185532-71-2) → ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate (200726-99-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃;

DOI:10.1016/S0960-894X(99)00654-X

Reference yield:

4-hydroxy-8-methyl-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-2-one (200726-79-0) → ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate (200726-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / DMAP / CH₂Cl₂ / 20 °C

2: 49 percent / PPh₃; EtO₂CN=NCCO₂Et / CH₂Cl₂ / 20 °C

With dmap; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; 1: Condensation / 2: Mitsunobu reaction;

DOI:10.1016/S0960-894X(99)00654-X

Reference yield:

→ ethyl 8-methyl-2-oxo-4-(phenylmethoxy)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate (200726-99-4)

Guidance literature:

upstream raw materials:

ethyl 4-hydroxy-8-methyl-2-oxo-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-3-carboxylate

benzyl alcohol

4-hydroxy-8-methyl-7-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-1-benzopyran-2-one

Downstream raw materials:

4-Benzyloxy-7-((2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester

ethyl 7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)-oxy)-8-methyl-2-oxo-4-(phenylmethoxy)-2H-1-benzopyran-3-carboxylate

ethyl 7-hydroxy 8-methyl-2-oxo-4-(phenyl-methoxy)-2H-1-benzopyran-3-carboxylate

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