4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone

Base Information

• Chemical Name: 4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone
• CAS No.: 1402042-93-6
• Molecular Formula: C₁₄H₁₀FN₅S
• Molecular Weight: 299.331

Synonyms:4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone

Chemical Property of 4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone

Chemical Property:

Purity/Quality:

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Technology Process of 4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone

There total 2 articles about 4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.02%

1-(5-(pyridine-3-yl)-1,3,4-thiadiazol-2-yl)hydrazine (299170-25-5) + 4-fluorobenzaldehyde (459-57-4) → 4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone (1402042-93-6)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1002/jhet.870

Reference yield:

3-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine (1334309-65-7) → 4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone (1402042-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1 h / Reflux

2: methanol / 20 °C

With hydrazine hydrate; In methanol; ethanol;

DOI:10.1002/jhet.870

Reference yield: 69.26%

4-fluorobenzaldehyde 1-(5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)hydrazone (1402042-93-6) → 3-(4-fluorophenyl)-6-(pyridine-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (151297-75-5)

Guidance literature:

With chloroamine-T; In ethanol; at 20 ℃;

DOI:10.1002/jhet.870

upstream raw materials:

3-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine

1-(5-(pyridine-3-yl)-1,3,4-thiadiazol-2-yl)hydrazine

4-fluorobenzaldehyde

Downstream raw materials:

3-(4-fluorophenyl)-6-(pyridine-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

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