2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester

Base Information

• Chemical Name: 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester
• CAS No.: 279245-99-7
• Molecular Formula: C₂₆H₂₁ClO₄S
• Molecular Weight: 464.969
• Mol file: 279245-99-7.mol

Synonyms:2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester

Chemical Property of 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester

There total 2 articles about 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

1-methoxycarbonyl-2-(bromomethyl)naphthalene (2417-76-7) + 4-chloro-4'-(methylsulfonyl)-1,1'-biphenyl → 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester (279245-99-7)

Guidance literature:

4-chloro-4'-(methylsulfonyl)-1,1'-biphenyl; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h;

1-methoxycarbonyl-2-(bromomethyl)naphthalene; In tetrahydrofuran; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/jm020160g

Reference yield:

lithiosulfone + 1-methoxycarbonyl-2-(bromomethyl)naphthalene (2417-76-7) → 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester (279245-99-7)

Guidance literature:

In tetrahydrofuran; ethyl acetate;

Reference yield: 20.0%

2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid methyl ester (279245-99-7) → 2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid (279246-00-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 16h;

DOI:10.1021/jm020160g

upstream raw materials:

1-methoxycarbonyl-2-(bromomethyl)naphthalene

Downstream raw materials:

2-[2-[(4'-chloro[1,1'-biphenyl]-4-yl)sulfonyl]ethyl]-1-naphthalenecarboxylic acid