(S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Base Information

Chemical Name:(S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
CAS No.:899818-39-4
Molecular Formula:C₂₇H₃₆N₂O₆SSi
Molecular Weight:544.744
Hs Code.:

Synonyms:(S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

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Chemical Property of (S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

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Technology Process of (S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

There total 13 articles about (S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 120506-39-0
(4-(bromomethyl)phenoxy) (tert-butyl) dimethylsilane

: 220509-74-0,1110670-49-9
(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

: 899818-39-4
(S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Guidance literature:: (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(4-(bromomethyl)phenoxy)(tert-butyl)dimethylsilane; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm051217c

Reference yield: 47.0%

: 899818-39-4
(S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Guidance literature:

Reference yield:

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 899818-39-4
(S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2.05 g / N,N-diisopropylethylamine / tetrahydrofuran; CHCl₃ / 0.5 h

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 47 percent / dimethylformamide / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm051217c