ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate
CAS No.:1572403-09-8
Molecular Formula:C₁₈H₂₀F₂N₂O₅S
Molecular Weight:414.43
Hs Code.:

Synonyms:ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

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Chemical Property of ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

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Technology Process of ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

There total 6 articles about ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 406482-20-0
(2,6-difluoro-4-methoxyphenyl)boronic acid

: 1395284-70-4
ethyl 2-bromo-5-((tert-butoxycarbonyl)amino)thiazole-4-carboxylate

: 1572403-09-8
ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; water; at 100 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1759-25-7
ethyl 2-cyano-2-(formyl-amino)acetate

: 1572403-09-8
ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; Lawessons reagent / 16 h / 20 - 120 °C

2: acetonitrile / 68 h / 20 °C

3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

4: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; water / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With Lawessons reagent; pyridine; potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tri-tert-butyl phosphine; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 18903-18-9
5-amino-thiazole-4-carboxylic acid ethyl ester

: 1572403-09-8
ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluoro-4-methoxyphenyl)thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 68 h / 20 °C

2: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

3: potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; water / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tri-tert-butyl phosphine; In tetrahydrofuran; dichloromethane; water; acetonitrile;