3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

Base Information

Chemical Name:3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid
CAS No.:1069045-90-4
Molecular Formula:C₂₆H₂₃F₂NO₃
Molecular Weight:435.47
Hs Code.:

Synonyms:3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

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Chemical Property of 3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

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Technology Process of 3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

There total 7 articles about 3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1069048-57-2
ethyl 3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoate

: 1069045-90-4
3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

Guidance literature:: ethyl 3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoate; With sodium hydroxide; In tetrahydrofuran; ethanol; water; Heating;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; pH=1;
DOI:10.1021/jm500494y

Reference yield:

: 127876-36-2
2-(benzotriazol-1-yl)acetophenone

: 1069045-90-4
3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium tetrachloride / dichloromethane / 3 h / 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C

3.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 110 °C

4.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

5.1: johnphos; potassium phosphate; palladium diacetate / acetic acid butyl ester / 110 - 120 °C

6.1: sodium hydroxide / water; tetrahydrofuran; ethanol / Heating

6.2: pH 1

With potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; titanium tetrachloride; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid butyl ester; water; toluene; 3.1: |Heck Reaction;
DOI:10.1021/jm500494y

Reference yield:

: 1069051-39-3
1-(5-bromo-1H-indol-3-yl)-2-phenylethanone

: 1069045-90-4
3-{1-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-1H-indol-5-yl}propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C

2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 110 °C

3.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C

4.1: johnphos; potassium phosphate; palladium diacetate / acetic acid butyl ester / 110 - 120 °C

5.1: sodium hydroxide / water; tetrahydrofuran; ethanol / Heating

5.2: pH 1

With potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos; In tetrahydrofuran; diethyl ether; ethanol; acetic acid butyl ester; water; toluene; 2.1: |Heck Reaction;
DOI:10.1021/jm500494y