Technology Process of (3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-6-hydroxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[b]azocin-5-one
There total 13 articles about (3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-6-hydroxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[b]azocin-5-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; hydrogen;
10percent Pd/C;
In
methanol;
for 84h;
under 3102.97 Torr;
DOI:10.1021/jo0206521
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 75 percent / thionyl chloride / benzene / 3 h / Heating
2.1: 76 percent / pyridine / 14 h / 65 °C
3.1: 72 percent / KHMDS / tetrahydrofuran / 2 h / -20 - 3 °C
4.1: 97 percent / LiAlH4 / tetrahydrofuran / 0.33 h
5.1: oxalyl chloride; DMSO / CH2Cl2 / 3 h / -78 °C
5.2: 94 percent / triethylamine / CH2Cl2 / 0.17 h / -78 °C
6.1: 93 percent / p-toluenesulfonic acid / tetrahydrofuran; ethanol / 5 h / 20 °C
7.1: Triton B / dimethylsulfoxide; methanol / 20 °C
7.2: 97 percent / dimethylsulfoxide; methanol / 1.5 h / 65 °C
8.1: 77 percent / tert-butyl hydroperoxide; Triton B / tetrahydrofuran; methanol / 0.33 h / 20 °C
9.1: 90 percent / H2; pyridine / 10percent Pd/C / methanol / 84 h / 3102.97 Torr
With
pyridine; tert.-butylhydroperoxide; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; hydrogen; N-benzyl-trimethylammonium hydroxide; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide;
10percent Pd/C;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; benzene;
5.1: Swern oxidation;
DOI:10.1021/jo0206521
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: K3PO4; Pb(NO3)2 / acetonitrile / 36 h / 20 °C
1.2: 16.26 g / hydrochloric acid / methanol; H2O / 1 h / Heating
2.1: 76 percent / pyridine / 14 h / 65 °C
3.1: 72 percent / KHMDS / tetrahydrofuran / 2 h / -20 - 3 °C
4.1: 97 percent / LiAlH4 / tetrahydrofuran / 0.33 h
5.1: oxalyl chloride; DMSO / CH2Cl2 / 3 h / -78 °C
5.2: 94 percent / triethylamine / CH2Cl2 / 0.17 h / -78 °C
6.1: 93 percent / p-toluenesulfonic acid / tetrahydrofuran; ethanol / 5 h / 20 °C
7.1: Triton B / dimethylsulfoxide; methanol / 20 °C
7.2: 97 percent / dimethylsulfoxide; methanol / 1.5 h / 65 °C
8.1: 77 percent / tert-butyl hydroperoxide; Triton B / tetrahydrofuran; methanol / 0.33 h / 20 °C
9.1: 90 percent / H2; pyridine / 10percent Pd/C / methanol / 84 h / 3102.97 Torr
With
pyridine; tert.-butylhydroperoxide; potassium phosphate; lithium aluminium tetrahydride; lead(II) nitrate; oxalyl dichloride; hydrogen; N-benzyl-trimethylammonium hydroxide; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide;
10percent Pd/C;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
5.1: Swern oxidation;
DOI:10.1021/jo0206521