methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

Base Information

Chemical Name:methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate
CAS No.:1452489-38-1
Molecular Formula:C₂₆H₃₀N₂O₄S
Molecular Weight:466.601
Hs Code.:

Synonyms:methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

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Chemical Property of methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

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Technology Process of methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

There total 5 articles about methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877-42-9
6-Bromo-2-methyl-quinoline

: 1452489-38-1
methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

: 1452489-39-2
methyl (E)-3-(2-(N-(2-(2-methylquinolin-6-yl)hexyl)sulfamoyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Schlenk technique; Inert atmosphere

1.2: -78 - 20 °C / Schlenk technique; Inert atmosphere

2.1: nickel(II) bromide dimethoxyethane; lithium chloride / tetrahydrofuran; hexane / 12 h / 23 °C / Schlenk technique; Inert atmosphere

With n-butyllithium; nickel(II) bromide dimethoxyethane; lithium chloride; In tetrahydrofuran; hexane; 2.1: |Negishi Coupling;
DOI:10.1021/ja4076716

Reference yield:

: 1452490-04-8
(2-methylquinolin-6-yl)zinc(II) bromide

: 1452489-72-3
methyl (E)-3-(2-((2-butylaziridin-1-yl)sulfonyl)phenyl)acrylate

: 1452489-38-1
methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

: 1452489-39-2
methyl (E)-3-(2-(N-(2-(2-methylquinolin-6-yl)hexyl)sulfamoyl)phenyl)acrylate

Guidance literature:: With nickel(II) bromide dimethoxyethane; lithium chloride; In tetrahydrofuran; hexane; at 23 ℃; for 12h; Overall yield = 26%; Overall yield = 11.0 mg; regioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja4076716

Reference yield:

: methyl (E)-3-(2-(chlorosulfonyl)phenyl)acrylate

: 1452489-38-1
methyl (E)-3-(2-(N-(1-(2-methylquinolin-6-yl)hexan-2-yl)sulfamoyl)phenyl)acrylate

: 1452489-39-2
methyl (E)-3-(2-(N-(2-(2-methylquinolin-6-yl)hexyl)sulfamoyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / chloroform / 1 h / 0 - 23 °C / Schlenk technique

2: nickel(II) bromide dimethoxyethane; lithium chloride / tetrahydrofuran; hexane / 12 h / 23 °C / Schlenk technique; Inert atmosphere

With nickel(II) bromide dimethoxyethane; triethylamine; lithium chloride; In tetrahydrofuran; hexane; chloroform; 2: |Negishi Coupling;
DOI:10.1021/ja4076716