(E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

Base Information

Chemical Name:(E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide
CAS No.:1268243-07-7
Molecular Formula:C₂₀H₂₁N₃O₃
Molecular Weight:351.405
Hs Code.:

Synonyms:(E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

Suppliers and Price of (E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

Chemical Property:

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Technology Process of (E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

There total 4 articles about (E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: (2E)-3-{4-[(3-methylbut-2-enyl)oxy]phenyl}prop-2-enoic acid

: 54-85-3,7640-37-1
isoniazid

: 1268243-07-7
(E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm101510d

Reference yield:

: 3943-97-3
methyl 4-hydroxycinnamate

: 1268243-07-7
(E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetone / 20 h / Reflux

2: water; potassium carbonate / methanol / 3 h / Reflux

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium iodide; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm101510d

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 1268243-07-7
(E)-N'-{3-[4-(3-methylbut-2-enyloxy)phenyl]propenoyl}isonicotinohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 24 h / Molecular sieve

2: potassium carbonate; potassium iodide / acetone / 20 h / Reflux

3: water; potassium carbonate / methanol / 3 h / Reflux

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With sulfuric acid; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium iodide; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm101510d