Technology Process of N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-7-[2-(dimethylamino)ethoxy]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide
There total 6 articles about N-benzyl-2-{1-[(3,4-dimethoxyphenyl)methyl]-7-[2-(dimethylamino)ethoxy]-6-methoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm400720h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: trichlorophosphate / toluene / 2 h / 90 °C
3: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400720h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: trichlorophosphate / toluene / 2 h / 90 °C
3: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
5: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400720h
