allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

Base Information

Chemical Name:allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate
CAS No.:1592908-68-3
Molecular Formula:C₄₀H₄₂BrN₃O₈
Molecular Weight:772.693
Hs Code.:

Synonyms:allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

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Chemical Property of allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

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Technology Process of allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

There total 7 articles about allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2901-99-7,4427-08-1,36578-01-5,70050-93-0,77481-37-9
2-benzamido-3-methylpentanoic acid

: 1592908-64-9
allyl (2R,3S)-2-((4-bromobenzylamino)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

: 1592908-68-3
allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; PyBroP; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201301769

Reference yield: 60.0%

: 1592908-64-9
allyl (2R,3S)-2-((4-bromobenzylamino)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

: 1592907-23-7
C₁₉H₁₉NO₃

: 1592908-68-3
allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1016896-54-0
(2S,3S)-ethyl-3-(allyloxycarbonylamino)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-carboxylate

: 1592908-68-3
allyl (2R,3S)-2-(((S)-2-benzamido-N-(4-bromobenzyl)-3-phenylpropanamido)methyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate; diphenylphosphoranyl azide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

4: sodium cyanoborohydride; acetic acid / ethanol / 4 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; PyBroP / dichloromethane / 20 °C / Inert atmosphere

With lithium borohydride; diphenylphosphoranyl azide; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; PyBroP; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/ejoc.201301769