5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Base Information

• Chemical Name: 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile
• CAS No.: 1528745-21-2
• Molecular Formula: C₃₆H₃₀NO₃PS
• Molecular Weight: 587.679

Synonyms:5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Chemical Property of 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

Chemical Property:

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Technology Process of 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

There total 3 articles about 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ5-phosphanylidene)butanenitrile (1528745-19-8) + 2-methylbenzyl bromide (89-92-9) → 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ5-phosphanylidene)pentanenitrile (1528745-21-2)

Guidance literature:

3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)butanenitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h; Inert atmosphere;

2-methylbenzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.5012/bkcs.2013.34.10.2953

Reference yield:

benzenesulfonylacetic acid (3959-23-7) → 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ5-phosphanylidene)pentanenitrile (1528745-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane; dmap / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; 1,2-dichloro-ethane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2013.34.10.2953

Reference yield:

cyanomethylene triphenylphosphorane (16640-68-9) → 5-(2-methylphenyl)-3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ5-phosphanylidene)pentanenitrile (1528745-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane; dmap / dichloromethane / 13 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; 1,2-dichloro-ethane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2013.34.10.2953

upstream raw materials:

benzenesulfonylacetic acid

cyanomethylene triphenylphosphorane

3-oxo-4-(phenylsulfonyl)-2-(triphenyl-λ⁵-phosphanylidene)butanenitrile

2-methylbenzyl bromide

Downstream raw materials:

5-(2-methylphenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanenitrile

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