3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid
• CAS No.: 191801-94-2
• Molecular Formula: C₁₇H₁₃NO₄
• Molecular Weight: 295.295
• Mol file: 191801-94-2.mol

Synonyms:3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid

Chemical Property of 3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid

There total 5 articles about 3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-Methoxyphenylacetic acid (104-01-8) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 2-hydroxy-3-(4-methoxyphenyl)quinoline-4-carboxylic acid (191801-94-2)

Guidance literature:

With sodium acetate; at 200 ℃; for 3h;

DOI:10.1016/j.bmc.2007.12.028

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid (191801-94-2)

Guidance literature:

With sodium acetate; at 150 - 200 ℃;

Reference yield:

aniline (62-53-3) → 3-(4-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-4-carboxylic acid (191801-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium sulfate; hydroxylamine hydrochloride; hydrogenchloride / water / 2 h / 45 °C

2: methanesulfonic acid / 0.25 h / 50 - 80 °C

3: sodium acetate / 150 - 200 °C

With hydrogenchloride; methanesulfonic acid; hydroxylamine hydrochloride; sodium acetate; sodium sulfate; In water;

upstream raw materials:

4-Methoxyphenylacetic acid

indole-2,3-dione

hydroxyimino-N-phenylacetamide

aniline