methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate

Base Information

• Chemical Name: methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate
• CAS No.: 128117-24-8
• Molecular Formula: C₂₂H₂₅NO₄S
• Molecular Weight: 399.511
• Mol file: 128117-24-8.mol

Synonyms:methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate

Chemical Property of methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate

There total 4 articles about methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-benzylacrylate (3070-71-1) + 3-(acetylthio)-1-(benzyloxycarbonyl)azetidine (128117-23-7) → methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate (128117-24-8)

Guidance literature:

With sodium hexamethyldisilazane; Yield given. Multistep reaction; 1.) MeOH, THF, 45 min, 2.) MeOH, THF, 45 min;

DOI:10.1021/jm00056a006

Reference yield:

methyl 2-benzylacrylate (3070-71-1) → methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate (128117-24-8)

Guidance literature:

With hydrogenchloride; sodium methylate; sodium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane;

Reference yield:

2-Benzyl-2-propenoic acid (5669-19-2) → methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate (128117-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / BF₃*Et₂O / 14 h / Heating

2: 1.) sodium bis(trimethylsilyl)amide / 1.) MeOH, THF, 45 min, 2.) MeOH, THF, 45 min

With boron trifluoride diethyl etherate; sodium hexamethyldisilazane;

DOI:10.1021/jm00056a006

upstream raw materials:

methyl 2-benzylacrylate

3-(acetylthio)-1-(benzyloxycarbonyl)azetidine

2-Benzyl-2-propenoic acid

1-Benzyloxycarbonyl-3-hydroxyazetidine

Downstream raw materials:

methyl 2-Benzyl-3-(1-benzyloxycarbonyl-azetidin-3-ylsulfonyl)propionate

methyl 2-Benzyl-3-(1-methylazetidin-3-ylsulfonyl)propionate