3-FLUORO-4-METHOXYPHENOL

Base Information

• Chemical Name: 3-FLUORO-4-METHOXYPHENOL
• CAS No.: 452-11-9
• Molecular Formula: C7H7FO2
• Molecular Weight: 142.13
• Hs Code.: 2909500000
• Mol file: 452-11-9.mol

Synonyms:3-FLUORO-4-METHOXYPHENOL;4-Aminomethyl-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;2-Fluoro-4-hydroxyanisole

Chemical Property of 3-FLUORO-4-METHOXYPHENOL

Chemical Property:

• Vapor Pressure: 0.016mmHg at 25°C
• Melting Point: 54-55 °C
• Refractive Index: 1.512
• Boiling Point: 248.243 °C at 760 mmHg
• PKA: 9.46±0.18(Predicted)
• Flash Point: 121.424 °C
• PSA: 29.46000
• Density: 1.224g/cm³
• LogP: 1.53990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Fluoro-4-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-4-methoxyphenol is used in the preparation of non-peptidic NPBWR1 (GPR7) antagonists.

Technology Process of 3-FLUORO-4-METHOXYPHENOL

There total 12 articles about 3-FLUORO-4-METHOXYPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

acetic acid 3-fluoro-4-methoxyphenyl ester (946833-20-1) → 3-fluoro-4-methoxyphenol (452-11-9)

Guidance literature:

With sodium hydroxide; water; In ethanol; at 20 ℃; for 3h;

Reference yield: 73.0%

bromo(3-fluoro-4-methoxyphenyl)magnesium → 3-fluoro-4-methoxyphenol (452-11-9)

Guidance literature:

With air; In tetrahydrofuran; at -25 ℃; for 0.0566667h; under 12929 Torr; Green chemistry;

DOI:10.1002/anie.201310572

Reference yield: 70.0%

Diethoxy-(3-fluoro-4-methoxy-phenyl)-methyl-silane → 3-fluoro-4-methoxyphenol (452-11-9)

Guidance literature:

With potassium fluoride; dihydrogen peroxide; In ethanol; for 18h; Heating;

upstream raw materials:

3-fluoro-4-methoxyaniline

1-fluoro-2-methoxybenzene

2-fluoro-1-methoxy-4-nitrobenzene

acetic acid 3-fluoro-4-methoxyphenyl ester

Downstream raw materials:

4-(2,6-diiodo-4-nitro-phenoxy)-2-fluoro-1-methoxy-benzene

2-[(3-Fluoro₄-methoxy)phenoxy]tetrahydropyran

2-fluoro-1-methoxy-4-methoxymethoxy-benzene

2-(3-fluoro-4-methoxyphenoxy)-N-(2-oxo-1,2-dihydropyridin-4-yl)-4-(trifluoromethyl)benzamide

Refernces

• 1、 Gao, Hongyin,Zhou, Zhe,Kwon, Doo-Hyun,Coombs, James,Jones, Steven,Behnke, Nicole Erin,Ess, Daniel H.,Kürti, László. "Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds". . p. 681 - 688. Retrieved 2017/06/30.
• 2、 -. "LABELED PKG-1-ALPHA-BINDING COMPOUNDS AND THEIR USE IN IMAGING AND QUANTIFYING PAIN". Page/Page column 8. . Retrieved 2015/01/16.