(S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

Base Information

Chemical Name:(S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one
CAS No.:1351958-00-3
Molecular Formula:C₄₀H₅₄F₆O₈
Molecular Weight:776.854
Hs Code.:

Synonyms:(S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

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Chemical Property of (S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

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Technology Process of (S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

There total 19 articles about (S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 868836-97-9
(3R,7R,11R,15R)-1,11,16-trihydroxy-3,7,11,15-tetramethylhexadecan-4-one

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1351958-00-3
(S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

Guidance literature:: With pyridine; In dichloromethane; at -5 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201400714

Reference yield:

: 868836-97-9
(3R,7R,11R,15R)-1,11,16-trihydroxy-3,7,11,15-tetramethylhexadecan-4-one

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

: 1351958-00-3
(S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja2082679

Reference yield:

: 1350642-97-5
(3R,7R,11R,15R)-1,16-bis(4-(4,4,5,5,6,6,7,7,7-nonafluoroheptyloxy)benzyloxy)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

: 1351958-00-3
(S,3R,7R,11R,15R,S’)-1,16-(bis-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)-11-hydroxy-3,7,11,15-tetramethylhexadecan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 48 h

2: dicyclohexyl-carbodiimide / dichloromethane / 24 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1021/ja2082679