(4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

Base Information

Chemical Name:(4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione
CAS No.:541508-62-7
Molecular Formula:C₁₉H₁₈N₂O₂S
Molecular Weight:338.43
Hs Code.:

Synonyms:(4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

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Chemical Property of (4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

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Technology Process of (4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

There total 11 articles about (4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 112878-95-2
(4R,5R)-1,3-dibenzyl-5-(mercaptomethyl)imidazolidin-2-one-4-carboxylic acid

: 541508-62-7
(4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In chloroform; at 25 ℃; for 1h;
DOI:10.1002/chem.200400733

Reference yield:

: C₂₀H₂₃N₃OS

: 28092-52-6
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

: 541508-62-7
(4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

Guidance literature:: C₂₀H₂₃N₃OS; With phosgene; sodium hydroxide; In water; 1,2-dichloro-ethane; at 0 ℃; for 2h; pH=10 - 12;

With sulfuric acid; at 80 - 82 ℃; for 5h; Reagent/catalyst; Overall yield = 30.8 g; Reflux;

Reference yield:

: (R)-2-benzylamino-3-acetylmercaptopropanol

: 28092-52-6
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

: 541508-62-7
(4R,5R)-1,3-dibenzyl-3,3a,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 4 h / 0 - 20 °C / Reflux

1.2: 2 h / 0 - 20 °C

2.1: water / 2 h / -25 - 20 °C

2.2: 3 h / -35 °C

3.1: phosgene; sodium hydroxide / water; 1,2-dichloro-ethane / 2 h / 0 °C / pH 10 - 12

3.2: 5 h / 80 - 82 °C / Reflux

With phosgene; sulfur trioxide pyridine complex; sodium hydroxide; In water; dimethyl sulfoxide; 1,2-dichloro-ethane;