4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

Base Information

Chemical Name:4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile
CAS No.:168567-22-4
Molecular Formula:C₂₉H₅₀INO₇Si₂
Molecular Weight:707.794
Hs Code.:

Synonyms:4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

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Chemical Property of 4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

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Technology Process of 4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

There total 7 articles about 4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 168567-21-3
4-<(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

: 168567-22-4
4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

Guidance literature:: With pyridine; dmap; In dichloromethane; for 14h; Ambient temperature;
DOI:10.1021/ja00126a013

Reference yield:

: 168567-32-6
4-<(2-O-acetyl-6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

: 168567-22-4
4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / MeONa / methanol / 13 h / -20 °C

2: 100 percent / pyridine, DMAP / CH₂Cl₂ / 14 h / Ambient temperature

With pyridine; dmap; sodium methylate; In methanol; dichloromethane;
DOI:10.1021/ja00126a013

Reference yield:

: 4-<(2-O-acetyl-6-deoxy-4-O-<(1,1-dimethylethyl)dimethylsilyl>-3-O-methyl-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

: 168567-22-4
4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Bu₄NF / tetrahydrofuran / 5 h / 0 °C

2: 94 percent / MeONa / methanol / 13 h / -20 °C

3: 100 percent / pyridine, DMAP / CH₂Cl₂ / 14 h / Ambient temperature

With pyridine; dmap; tetrabutyl ammonium fluoride; sodium methylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00126a013