(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine

Base Information

• Chemical Name: (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine
• CAS No.: 1009582-71-1
• Molecular Formula: C₃₁H₃₁N₃O₂S
• Molecular Weight: 509.672
• Mol file: 1009582-71-1.mol

Synonyms:(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine

Chemical Property of (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine

There total 1 articles about (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4S,5S)-2-(chloromethyl)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazole (870559-17-4) + (S)-1-phenyl-ethylamine (2627-86-3) → (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine (1009582-71-1)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1002/chem.200701439

Reference yield: 68.0%

3,5-Dibromosalicylaldehyde (90-59-5) + (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine (1009582-71-1) → 2-{[(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamino]methyl}-4,6-dibromophenol (1009582-56-2)

Guidance literature:

3,5-Dibromosalicylaldehyde; (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine; In methanol; at 20 ℃; for 1h;

With sodium cyanoborohydride; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

DOI:10.1002/chem.200701439

Reference yield: 35.0%

3-bromo-5-nitrosalicylaldehyde (16789-84-7) + (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine (1009582-71-1) → 6-bromo-2-(((((4S,5S)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazol-2-yl)methyl)((S)-1-phenylethyl)amino)methyl)-4-nitrophenol (1174172-63-4)

Guidance literature:

3-bromo-5-nitrosalicylaldehyde; (1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamine; In methanol; at 20 ℃; for 1h;

With sodium cyanoborohydride; In tetrahydrofuran; methanol; at 0 - 20 ℃;

DOI:10.1039/b904275j

upstream raw materials:

(4S,5S)-2-(chloromethyl)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazole

(S)-1-phenyl-ethylamine

Downstream raw materials:

2-{[(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamino]methyl}-4,6-dibromophenol

6-bromo-2-(((((4S,5S)-4,5-diphenyl-1-tosyl-4,5-dihydro-1H-imidazol-2-yl)methyl)((S)-1-phenylethyl)amino)methyl)-4-nitrophenol