(S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

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Chemical Name:(S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester
CAS No.:558481-40-6
Molecular Formula:C₃₆H₄₄N₂O₇
Molecular Weight:616.755
Hs Code.:

Synonyms:(S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

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Chemical Property of (S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

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Technology Process of (S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

There total 4 articles about (S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: (3S)-3-amino-4-cyclohexyl-4-oxobutyric acid methyl ester hydrobromide

: 558481-38-2
4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid

: 558481-40-6
(S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; for 0.5h;
DOI:10.1021/ol0345327

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 558481-40-6
(S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ni(dppe)Cl₂ / tetrahydrofuran / 48 h / 20 °C

1.2: CrO₃; aq. H₂SO₄ / acetone / 1 h / 0 °C

2.1: 62 percent / aq. HBr; phenol / 1.5 h / Heating

3.1: 88 percent / H₂SO₄ / 2 h / Heating

4.1: 54 percent / PyBOP; N,N-diisopropylethylamine / CHCl₃ / 0.5 h

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; N-ethyl-N,N-diisopropylamine; phenol; In tetrahydrofuran; chloroform; 1.2: Jones oxidation;
DOI:10.1021/ol0345327

Reference yield:

: 558481-26-8
(3S)-4-cyclohexyl-4-oxo-3-[(phenylsulfonyl)amino]butanoic acid

: 558481-40-6
(S)-4-Cyclohexyl-3-[(S)-4-cyclohexyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyrylamino]-4-oxo-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / aq. HBr; phenol / 1.5 h / Heating

2: 88 percent / H₂SO₄ / 2 h / Heating

3: 54 percent / PyBOP; N,N-diisopropylethylamine / CHCl₃ / 0.5 h

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; N-ethyl-N,N-diisopropylamine; phenol; In chloroform;
DOI:10.1021/ol0345327