Technology Process of 3(R)-benzyl-2-oxo-1-pyrrolidine-2(S)-hexanoic acid benzyl ester
There total 7 articles about 3(R)-benzyl-2-oxo-1-pyrrolidine-2(S)-hexanoic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH2Cl2 / 14 h
2: 1.) trimethyloxonium tetrafluoroborate, 2.) CH3CONCH3Li / 1) CH2Cl2, room temperature, 2 h; 2) THF, 0 deg C, 90 min
With
N-methylacetamidate lithium; trimethoxonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
dichloromethane;
DOI:10.1021/jm00402a021
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) lithium diisopropylamide / 1) THF, hexane, -78 deg C, 15 min; 2) -78 deg C --> room temperature, 30 min, THF, hexane
2: 80 percent / OsO4, NaIO4 / tetrahydrofuran; H2O / 0.33 h
3: 1.) 4-Angstroem molecular sieves, 2.) NaCNBH3, acetic acid / 1) THF, 30 min; 2) THF, 2 h
4: 1.) HCl, diisopropylethylamine,,diethyl phosphorocyanidate / 1) CH2Cl2, ether, 15 min; 2) CH2Cl2
With
hydrogenchloride; sodium periodate; osmium(VIII) oxide; diethyl cyanophosphonate; 4 A molecular sieve; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; water;
DOI:10.1021/jm00402a021
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH2Cl2 / 14 h
2: 1.) trimethyloxonium tetrafluoroborate, 2.) CH3CONCH3Li / 1) CH2Cl2, room temperature, 2 h; 2) THF, 0 deg C, 90 min
With
N-methylacetamidate lithium; trimethoxonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
dichloromethane;
DOI:10.1021/jm00402a021
