(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

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Chemical Name:(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate
CAS No.:1514894-40-6
Molecular Formula:C₃₉H₆₄N₂O₇Si₂
Molecular Weight:729.117
Hs Code.:

(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

Synonyms:(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

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Chemical Property of (4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

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Technology Process of (4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

There total 16 articles about (4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1514894-19-9
(2-nitro-4-(2-oxoethyl)-1H-pyrrol-1-yl)methyl benzoate

: 5-(((5R)-5-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-5-((triethylsilyl)oxy)pentan-2-yl)sulfonyl)-1-phenyl-1H-tetrazole

: 1514894-40-6
(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

: (4-((R,E)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

Guidance literature:: (2-nitro-4-(2-oxoethyl)-1H-pyrrol-1-yl)methyl benzoate; 5-(((5R)-5-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-5-((triethylsilyl)oxy)pentan-2-yl)sulfonyl)-1-phenyl-1H-tetrazole; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

(2-nitro-4-(2-oxoethyl)-1H-pyrrol-1-yl)methyl benzoate; In tetrahydrofuran; at -78 - 20 ℃; Overall yield = 30 %;
DOI:10.1021/ol403246j

Reference yield:

: 1514894-08-6
C₁₂H₁₀N₂O₄

: 1514894-40-6
(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / acetonitrile / 60 °C / Darkness

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / Inert atmosphere

3.1: sulfuric acid / acetonitrile; water

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

4.2: -78 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sulfuric acid; sodium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 2.1: |Stille Cross Coupling / 4.1: |Julia-Kocienski Olefination / 4.2: |Julia-Kocienski Olefination;
DOI:10.1021/ol403246j

Reference yield:

: 1514894-16-6
1-benzoyloxymethyl-2-nitro-4vinyl-pyrrole

: 1514894-40-6
(4-((R,Z)-3-methyl-6-((2S,5S)-2-methyl-5-(2-((triethylsilyl)oxy)propan-2-yl)tetrahydrofuran-2-yl)-6-((triethylsilyl)oxy)hex-2-en-1-yl)-2-nitro-1H-pyrrol-1-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / acetonitrile; water

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

2.2: -78 - 20 °C

With sulfuric acid; sodium hexamethyldisilazane; In tetrahydrofuran; water; acetonitrile; 2.1: |Julia-Kocienski Olefination / 2.2: |Julia-Kocienski Olefination;
DOI:10.1021/ol403246j