C₁₉H₂₅F₂NO₅

Base Information

• Chemical Name: C₁₉H₂₅F₂NO₅
• CAS No.: 845543-63-7
• Molecular Formula: C₁₉H₂₅F₂NO₅
• Molecular Weight: 385.408
• Mol file: 845543-63-7.mol

Synonyms:C₁₉H₂₅F₂NO₅

Chemical Property of C₁₉H₂₅F₂NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₅F₂NO₅

There total 5 articles about C₁₉H₂₅F₂NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C25H34F2N2O6 (845543-62-6) → C19H25F2NO5 (845543-63-7)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 18h;

Reference yield:

3,5-difluorocinnamic acid (84315-23-1) → C19H25F2NO5 (845543-63-7)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 5 h / 20 °C / 2585.81 Torr

2: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 20 - 23 °C

3: n-butyllithium / tetrahydrofuran; hexane / 15 h / -78 - 23 °C

4: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane / 4 h / -78 - 23 °C

5: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 18 h / 0 °C

With lithium hydroxide; n-butyllithium; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; hydrogen; dihydrogen peroxide; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

3-(3,5-difluorophenyl)propionic acid (84315-24-2) → C19H25F2NO5 (845543-63-7)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 20 - 23 °C

2: n-butyllithium / tetrahydrofuran; hexane / 15 h / -78 - 23 °C

3: di-n-butylboryl trifluoromethanesulfonate; triethylamine / dichloromethane / 4 h / -78 - 23 °C

4: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 18 h / 0 °C

With lithium hydroxide; n-butyllithium; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water;

upstream raw materials:

C₂₅H₃₄F₂N₂O₆

Preparation 8

3-(3,5-difluorophenyl)propionic acid

3-(3,5-difluorophenyl)propionyl chloride