Technology Process of 2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-isobutyl-1,3,4-oxadiazole
There total 4 articles about 2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-isobutyl-1,3,4-oxadiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-methylbutyric acid; 3-iodo-1-tosyl-1H-indole-5-carbohydrazide;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
trichlorophosphate;
at 110 ℃;
for 14h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: pH 4
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
2.2: 0 - 10 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 1.5 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2 h / 20 °C
4.2: 14 h / 110 °C / Inert atmosphere
With
iodine; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
1.2: 0 - 10 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 1.5 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2 h / 20 °C
3.2: 14 h / 110 °C / Inert atmosphere
With
sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
