1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne

Base Information

• Chemical Name: 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne
• CAS No.: 889361-58-4
• Molecular Formula: C₂₇H₄₈OSi₂
• Molecular Weight: 444.849
• Mol file: 889361-58-4.mol

Synonyms:1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne

Chemical Property of 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne

There total 3 articles about 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(triisopropylsilyl)-2-[4-(hydroxymethyl)phenyl]ethyne (889361-56-2) + triisopropylsilyl chloride (13154-24-0) → 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne (889361-58-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2006.02.016

Reference yield:

4-bromobenzenemethanol (873-75-6) → 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne (889361-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuI; tri-tert-butylphosphine; diisopropylamine / PdCl₂(PhCN)2 / dioxane / 4 h / 20 °C

2: 94 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; copper(l) iodide; tri-tert-butyl phosphine; diisopropylamine; bis(benzonitrile)palladium(II) dichloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tet.2006.02.016

Reference yield:

tris-iso-propylsilyl acetylene (89343-06-6) → 1-(triisopropylsilyl)-1-[4-(triisopropylsilyloxymethyl)phenyl]ethyne (889361-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuI; tri-tert-butylphosphine; diisopropylamine / PdCl₂(PhCN)2 / dioxane / 4 h / 20 °C

2: 94 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; copper(l) iodide; tri-tert-butyl phosphine; diisopropylamine; bis(benzonitrile)palladium(II) dichloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tet.2006.02.016

upstream raw materials:

1-(triisopropylsilyl)-2-[4-(hydroxymethyl)phenyl]ethyne

triisopropylsilyl chloride

4-bromobenzenemethanol

tris-iso-propylsilyl acetylene

Downstream raw materials:

(4-ethynylbenzyloxy)triisopropylsilane