2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid

Base Information

• Chemical Name: 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid
• CAS No.: 959857-77-3
• Molecular Formula: C₂₄H₂₆N₂O₄
• Molecular Weight: 406.481
• Mol file: 959857-77-3.mol

Synonyms:2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid

Chemical Property of 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid

There total 5 articles about 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid methyl ester → 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid (959857-77-3)

Guidance literature:

With pyridine; lithium iodide; Heating / reflux;

Reference yield:

(4-adamantan-1-yl-phenoxy)acetic acid (52804-26-9) → 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid (959857-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide

2: pyridine; lithium iodide

With pyridine; dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; lithium iodide; In N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2010.31.12.3826

Reference yield:

(4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester (52804-25-8) → 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinic acid (959857-77-3)

Guidance literature:

Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran

2: dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide

3: pyridine; lithium iodide

With pyridine; dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; lithium iodide; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.5012/bkcs.2010.31.12.3826

upstream raw materials:

(4-adamantan-1-yl-phenoxy)acetic acid

(4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester

4-adamantylphenol

methyl 2-aminoisonicotinate

Downstream raw materials:

2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-N-(furan-2-ylmethyl)-isonicotinamide

C₂₈H₃₄N₂O₄

C₂₈H₃₅N₃O₄