(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

Base Information

Chemical Name:(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid
CAS No.:1352007-71-6
Molecular Formula:C₂₄H₁₆F₄INO₄
Molecular Weight:585.293
Hs Code.:

Synonyms:(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

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Chemical Property of (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

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Technology Process of (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

There total 10 articles about (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₄F₄INO₄

: 1352007-71-6
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Darkness;
DOI:10.1039/C8CC06010J

Reference yield:

: 4-iodotetrafluorophenylalanine

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1352007-71-6
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

Guidance literature:: With sodium carbonate; In water; acetonitrile; at 20 ℃; for 2.5h;
DOI:10.1021/ol203140n

Reference yield:

: 136207-26-6,34702-60-8
(S)-2-((tert-butoxycarbonyl)amino)-3-(perfluorophenyl)propanoic acid

: 1352007-71-6
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2,3,5,6-tetrafluoro-4-iodophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane; cyclohexane / 16 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium azide; tetrabutylammoniun azide / N,N-dimethyl-formamide / 16 h / 80 °C

3.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 1 h / 20 °C

4.1: 18 h / 0 - 20 °C

5.1: 1.3-propanedithiol; N-ethyl-N,N-diisopropylamine / methanol; acetonitrile / 0.08 h / 20 °C

6.1: tert.-butylnitrite; iodine / acetonitrile / 1.5 h / 0 °C

7.1: hydrogenchloride / water / 16 h / Reflux

8.1: sodium carbonate / water; acetonitrile / 2.5 h / 20 °C

With 1.3-propanedithiol; hydrogenchloride; sodium azide; tert.-butylnitrite; chlorotriisopropylsilane; iodine; tetrabutylammoniun azide; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol203140n