(1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

Base Information

Chemical Name:(1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide
CAS No.:1025963-57-8
Molecular Formula:C₁₆H₂₇NO₂
Molecular Weight:265.396
Hs Code.:

Synonyms:(1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

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Chemical Property of (1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

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Technology Process of (1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

There total 3 articles about (1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027079-96-4
(4aR,8R,8aR)-8-isopropyl-5-methyl-1,4,4a,7,8,8a-hexahydroisochromen-3-one

: 1025963-57-8
(1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Me₃Al / hexane; toluene / 2 h / 20 °C

1.2: 94 percent / hexane; toluene / 2 h / 20 °C

2.1: 75 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1.17 h / -78 - 20 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 72 percent / hexane; tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; oxalyl dichloride; trimethylaluminum; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.1: Swern oxidation / 3.2: Wittig reaction;
DOI:10.1039/b207800g

Reference yield:

: (3R,3aR,7aR)-3-isopropyl-7b-methyloctahydro-1,5-dioxacyclopropa[α]naphthalen-6-one

: 1025963-57-8
(1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / Zn; NaI; NaOAc / CH₂Cl₂; acetic acid / 96 h / 20 °C

2.1: Me₃Al / hexane; toluene / 2 h / 20 °C

2.2: 94 percent / hexane; toluene / 2 h / 20 °C

3.1: 75 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1.17 h / -78 - 20 °C

4.1: n-BuLi / hexane; tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 72 percent / hexane; tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; oxalyl dichloride; trimethylaluminum; sodium acetate; dimethyl sulfoxide; triethylamine; sodium iodide; zinc; In tetrahydrofuran; hexane; dichloromethane; acetic acid; toluene; 3.1: Swern oxidation / 4.2: Wittig reaction;
DOI:10.1039/b207800g

Reference yield:

: 1026090-92-5
(1R,5R,6R)-2-(6-hydroxymethyl-5-isopropyl-2-methylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

: 1025963-57-8
(1R,5R,6R)-2-(5-isopropyl-2-methyl-6-vinylcyclohex-2-enyl)-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1.17 h / -78 - 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 72 percent / hexane; tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1.1: Swern oxidation / 2.2: Wittig reaction;
DOI:10.1039/b207800g