4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride

Base Information

• Chemical Name: 4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride
• CAS No.: 866774-40-5
• Molecular Formula: C₂₁H₂₂ClN₃O₄S₂
• Molecular Weight: 480.008

Synonyms:4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride

Chemical Property of 4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride

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Technology Process of 4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride

There total 1 articles about 4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(4-aminophenyl)-3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)propionamide (866774-39-2) → 4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride (866774-40-5)

Guidance literature:

2-(4-aminophenyl)-3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)propionamide; With hydrogenchloride; In water; acetic acid; at 0 ℃;

With sodium nitrite; In water; acetic acid;

With sulfur dioxide; copper dichloride; In water; acetic acid; at 20 ℃;

DOI:10.1021/jm900839k

Reference yield: 98.0%

4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride (866774-40-5) → 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-(4-sulfamoyl-phenyl)-propionamide

Guidance literature:

With ammonium bicarbonate; In water; acetone; at 20 ℃; for 1h;

DOI:10.1021/jm900839k

Reference yield: 71.0%

4-carbethoxypiperidine (1126-09-6) + 4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride (866774-40-5) → 1-{4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)-ethyl]-benzenesulfonyl}-piperidine-4-carboxylic acid ethyl ester (934266-86-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

2-(4-aminophenyl)-3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)propionamide

Downstream raw materials:

1-{4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)-ethyl]-benzenesulfonyl}-piperidine-4-carboxylic acid ethyl ester

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