N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-arginine n-butylmethylamide

Base Information

• Chemical Name: N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-arginine n-butylmethylamide
• CAS No.: 173440-67-0
• Molecular Formula: C₂₃H₃₉N₅O₅S
• Molecular Weight: 497.659
• Mol file: 173440-67-0.mol

Synonyms:N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-arginine n-butylmethylamide

Chemical Property of N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-arginine n-butylmethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-arginine n-butylmethylamide

There total 1 articles about N^α-(tert-butoxycarbonyl)-N^ω-tosyl-L-arginine n-butylmethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

N-n-butyl-N-methylamine (110-68-9) + Boc-Arg(Tos)-OH (13836-37-8) → Nα-(tert-butoxycarbonyl)-Nω-tosyl-L-arginine n-butylmethylamide (173440-67-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -10 - 5 ℃; for 14h;

DOI:10.1248/cpb.43.1683

Reference yield:

Nα-(tert-butoxycarbonyl)-Nω-tosyl-L-arginine n-butylmethylamide (173440-67-0) → C18H31N5O3S

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 1h; Ambient temperature;

DOI:10.1248/cpb.43.1683

Reference yield:

Nα-(tert-butoxycarbonyl)-Nω-tosyl-L-arginine n-butylmethylamide (173440-67-0) → Nα-(6,7-dimethoxy-2-naphthylsulfonyl)-Nω-tosyl-L-arginine n-butylmethylamide (173440-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 4N aq. HCl / ethyl acetate / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1.5 h / 4 °C

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1248/cpb.43.1683

upstream raw materials:

N-n-butyl-N-methylamine

Boc-Arg(Tos)-OH

Downstream raw materials:

N^α-(6,7-dimethoxy-2-naphthylsulfonyl)-N^ω-tosyl-L-arginine n-butylmethylamide