(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione
CAS No.:144100-61-8
Molecular Formula:C₂₉H₂₇FN₂O₄
Molecular Weight:486.543
Hs Code.:

Synonyms:(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

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Chemical Property of (+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

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Technology Process of (+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

There total 4 articles about (+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 76-83-5
trityl chloride

: 78336-03-5,144177-09-3
(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 144100-61-8
(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With pyridine; at 100 ℃; for 1h;
DOI:10.1139/v92-152

Reference yield:

: 62102-28-7,92007-59-5,99295-53-1,103302-19-8,103302-20-1,114129-20-3,120963-43-1,120963-44-2
(+/-)-1-<(1β,3β,4β)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-(1H,3H)-pyrimidine-2,4-dione

: 144100-61-8
(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / pyridine / 18 h / Ambient temperature

2: F₂ / acetic acid / 0.5 h

3: N(Et)3 / methanol; H₂O / 15 h / Ambient temperature

4: 90 percent / pyridine / 1 h / 100 °C

With pyridine; fluorine; triethylamine; In methanol; water; acetic acid;
DOI:10.1139/v92-152

Reference yield:

: 95313-01-2,97275-61-1,144177-08-2
(+/-)-1-<(1β,3β,4β)-3-acetoxy-4-(acetoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

: 144100-61-8
(+/-)-5-fluoro-1-<(1β,3β,4β)-3-hydroxy-4-(triphenylmethoxymethyl)cyclopentyl>-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: F₂ / acetic acid / 0.5 h

2: N(Et)3 / methanol; H₂O / 15 h / Ambient temperature

3: 90 percent / pyridine / 1 h / 100 °C

With pyridine; fluorine; triethylamine; In methanol; water; acetic acid;
DOI:10.1139/v92-152