(13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ⁵-phospha-cyclopenta[a]phenanthren-15-one

Base Information

• Chemical Name: (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ⁵-phospha-cyclopenta[a]phenanthren-15-one
• CAS No.: 81076-00-8
• Molecular Formula: C₂₈H₂₃O₂P
• Molecular Weight: 422.463

Synonyms:(13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ⁵-phospha-cyclopenta[a]phenanthren-15-one

Chemical Property of (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ⁵-phospha-cyclopenta[a]phenanthren-15-one

Chemical Property:

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Technology Process of (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ⁵-phospha-cyclopenta[a]phenanthren-15-one

There total 3 articles about (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ⁵-phospha-cyclopenta[a]phenanthren-15-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1R,2S)-2-((S)-Benzyl-phenyl-phosphinoyl)-1,2,3,4-tetrahydro-phenanthrene-1-carboxylic acid methyl ester (81075-99-2) → (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ5-phospha-cyclopenta[a]phenanthren-15-one (81076-00-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/jo00132a057

Reference yield:

1-vinylnaphthalene (826-74-4,29793-40-6) → (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ5-phospha-cyclopenta[a]phenanthren-15-one (81076-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃COOH / toluene / 40 h / 120 °C

2: 80 percent / NaH / tetrahydrofuran

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jo00132a057

Reference yield:

trans-benzylphenyl<β-(carbomethoxy)vinyl>phosphine oxide (81027-60-3) → (13S,14R,17R)-17-Oxo-16,17-diphenyl-11,12,13,14,16,17-hexahydro-17λ5-phospha-cyclopenta[a]phenanthren-15-one (81076-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃COOH / toluene / 40 h / 120 °C

2: 80 percent / NaH / tetrahydrofuran

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jo00132a057

upstream raw materials:

(1R,2S)-2-((S)-Benzyl-phenyl-phosphinoyl)-1,2,3,4-tetrahydro-phenanthrene-1-carboxylic acid methyl ester

1-vinylnaphthalene

trans-benzylphenyl<β-(carbomethoxy)vinyl>phosphine oxide

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