benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Base Information

Chemical Name:benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate
CAS No.:1193782-21-6
Molecular Formula:C₂₁H₂₆FN₃O₂
Molecular Weight:371.455
Hs Code.:

Synonyms:benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

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Technology Process of benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

There total 4 articles about benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1193782-19-2
benzyl (2S,4R)-4-cyano-4-[(3-fluorophenyl)amino]-2-methyl-piperidine-1-carboxylate

: 1193782-21-6
benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Guidance literature:: With ammonia; hydrogen; In methanol; water; for 12h; under 2585.81 Torr; Inert atmosphere;
DOI:10.1021/jm3009426

Reference yield: 77.0%

: 1193782-21-6
benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Guidance literature:

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1193782-21-6
benzyl (2S,4R)-4-(aminomethyl)-4-[(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 20 °C / Inert atmosphere

2: ammonia; hydrogen / methanol; water / 12 h / 2585.81 Torr / Inert atmosphere

With ammonia; hydrogen; acetic acid; In methanol; dichloromethane; water;
DOI:10.1021/jm3009426