methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate

Base Information

Chemical Name:methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate
CAS No.:70666-02-3
Molecular Formula:C₁₅H₁₈BrNO₄
Molecular Weight:356.216
Hs Code.:

Synonyms:methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate

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Technology Process of methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate

There total 3 articles about methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2295-35-4
pyrrolidin-2-thione

: 70666-01-2
methyl α-bromo-(2-bromo-4,5-dimethoxyphenyl)acetate

: 70666-02-3
methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate

Guidance literature:: With 3 A molecular sieve; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In chloroform; 1.) room temperature, 31 h, 2.) reflux, 88 h;
DOI:10.1039/P19800001607

Reference yield:

: 4697-57-8
methyl 2-(2-bromo-4,5-dimethoxyphenyl)acetate

: 70666-02-3
methyl (Z)-α-(2-bromo-4,5-dimethoxyphenyl)-α-pyrrolidin-2-ylideneacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / N-bromosuccinimide / CCl₄ / 192 h / Heating

2: 97 percent / molecular sieves 3 Angstroem 1/16, 1,5-diazabicyclo<5.4.0>undec-5-ene / CHCl₃ / 1.) room temperature, 31 h, 2.) reflux, 88 h

With N-Bromosuccinimide; 3 A molecular sieve; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In tetrachloromethane; chloroform;
DOI:10.1039/P19800001607