N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

Base Information

• Chemical Name: N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine
• CAS No.: 160375-50-8
• Molecular Formula: C₄₁H₄₇N₉O₇
• Molecular Weight: 777.88

Synonyms:N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

Chemical Property of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

There total 3 articles about N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-49-5) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-50-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at -10 ℃; for 2h;

Reference yield:

erythro-N?-Triphenylmethyl-β-hydroxy-L-histidinmethylester (142582-33-0) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / EDCI, HOBt / dimethylformamide / 48 h / 23 °C

2: 100 percent / 1 N aq. LiOH / tetrahydrofuran; methanol / 2 h / -10 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

3-(6-amino-4-carboxy-5-methylpyrimidin-2-yl)-3(S)-<(2-(((tert-butyloxy)carbonyl)amino)ethyl)amino>propionamide (157916-91-1) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / EDCI, HOBt / dimethylformamide / 48 h / 23 °C

2: 100 percent / 1 N aq. LiOH / tetrahydrofuran; methanol / 2 h / -10 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

erythro-N^?-Triphenylmethyl-β-hydroxy-L-histidinmethylester

3-(6-amino-4-carboxy-5-methylpyrimidin-2-yl)-3(S)-<(2-(((tert-butyloxy)carbonyl)amino)ethyl)amino>propionamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 160375-50-8 N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send