tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

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Chemical Name:tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate
CAS No.:1055307-07-7
Molecular Formula:C₂₄H₂₇F₂N₃O₆S₂
Molecular Weight:555.624
Hs Code.:

Synonyms:tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

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Chemical Property of tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

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Technology Process of tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

There total 19 articles about tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1055307-06-6
tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylthio)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

: 1055307-07-7
tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In ethyl acetate; at 0 ℃; for 2h;

Reference yield:

: 1055306-64-3
tert-butyl 3,3-difluoro-4-methylidene-2-oxopyrrolidine-1-carboxylate

: 1055307-07-7
tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.75 h / -78 °C

1.2: 3 h / -78 °C

2.1: hydrogenchloride; water; acetic acid / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

3.2: 1 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0.17 h / 0 °C

4.3: 0.25 h / 0 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

5.2: 16 h / 65 °C

5.3: 0.17 h / 20 °C

6.1: tetrahydrofuran / 0.08 h / 20 °C

7.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

8.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

10.1: dimethylsulfide borane complex / tetrahydrofuran; toluene / 24 h / 20 °C

11.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 60 h / 0 - 20 °C

12.1: potassium iodide / tetrahydrofuran; N,N-dimethyl-formamide / 97 h / 100 °C

13.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 0 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; dimethylsulfide borane complex; water; hydrogen; sodium hydride; acetic acid; methanesulfonyl chloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; isopropyl alcohol; potassium iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 3-(4,4-difluoro-3-methylidene-3,4-dihydro-2H-pyrrol-5-yl)-2-fluoropyridine

: 1055307-07-7
tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1-({3-[(methylsulfonyl)methyl]phenyl}sulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 60 °C

1.2: 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.17 h / 0 °C

2.3: 0.25 h / 0 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 65 °C

3.3: 0.17 h / 20 °C

4.1: tetrahydrofuran / 0.08 h / 20 °C

5.1: sodium hydroxide; water; isopropyl alcohol / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: 15-crown-5; sodium hydride / tetrahydrofuran / 1 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

8.1: dimethylsulfide borane complex / tetrahydrofuran; toluene / 24 h / 20 °C

9.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 60 h / 0 - 20 °C

10.1: potassium iodide / tetrahydrofuran; N,N-dimethyl-formamide / 97 h / 100 °C

11.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 0 °C

With sodium hydroxide; 15-crown-5; carbonochloridic acid 1-chloro-ethyl ester; dimethylsulfide borane complex; water; hydrogen; sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; isopropyl alcohol; potassium iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;