4-Amino-2-fluoropyridine

Base Information

• Chemical Name: 4-Amino-2-fluoropyridine
• CAS No.: 18614-51-2
• Molecular Formula: C5H5FN2
• Molecular Weight: 112.107
• Hs Code.: 2933399090
• European Community (EC) Number: 687-131-2
• DSSTox Substance ID: DTXSID20376491
• Wikidata: Q72437428
• Mol file: 18614-51-2.mol

Synonyms:4-Amino-2-fluoropyridine;18614-51-2;2-fluoropyridin-4-amine;2-FLUORO-PYRIDIN-4-YLAMINE;4-PYRIDINAMINE, 2-FLUORO-;MFCD03095284;2-FLUORO-4-AMINOPYRIDINE;SCHEMBL240296;DTXSID20376491;4-Amino-2-fluoropyridine, 96%;JSAKBYXSHKYFQU-UHFFFAOYSA-N;BBL100669;STL554463;AKOS005145585;CS-W007675;PB21208;AC-27367;DS-10521;SY011171;A4117;AM20070130;FT-0649139;EN300-77431;J-514333

Chemical Property of 4-Amino-2-fluoropyridine

Chemical Property:

• Vapor Pressure: 0.00994mmHg at 25°C
• Melting Point: 83-88°C
• Refractive Index: 1.554
• Boiling Point: 264 °C at 760 mmHg
• PKA: 3.76±0.30(Predicted)
• Flash Point: 113.5 °C
• PSA: 38.91000
• Density: 1.257g/cm³
• LogP: 1.38410
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 112.04367633
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-2-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1N)F
• Uses: 4-Amino-2-fluoropyridine is a useful synthesis intermediate.

Technology Process of 4-Amino-2-fluoropyridine

There total 1 articles about 4-Amino-2-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-fluoro-4-aminopyridine (18614-51-2)

Guidance literature:

2-Fluor-4-nitro-pyridin, Fe-Pulver, Eg.;

Reference yield: 67.0%

m-nitrobromobenzene (585-79-5) + 2-fluoro-4-aminopyridine (18614-51-2) → C11H8FN3O2

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃;

Reference yield: 54.0%

2-fluoro-4-aminopyridine (18614-51-2) + aniline (62-53-3) → 4-amino-2-anilinopyridine (25194-51-8)

Guidance literature:

at 150 ℃;

Downstream raw materials:

N-(2-fluoro-pyridin-4-yl)-N'-phenylurea

C₁₉H₂₈FN₃O₃

C₁₇H₁₄F₂N₄O

N-benzylidene-2-fluoropyridin-4-amine