Technology Process of 4-allyl-2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole
There total 9 articles about 4-allyl-2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: phosphorus pentachloride / hexane / 1.17 h / 0 - 20 °C
2: ammonium hydroxide / hexane / 3 h / 0 °C
3: Lawessons reagent / dichloromethane / 24 h
4: tetrahydrofuran / 2 h / 20 °C
5: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C
6: diisobutylaluminium hydride / diethyl ether / 1 h / -78 °C
7: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
8: indium(III) chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; dichloromethane / Heating
With
Lawessons reagent; pyridine; indium(III) chloride; ammonium hydroxide; carbon tetrabromide; phosphorus pentachloride; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic anhydride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/ejoc.200600671
- Guidance literature:
-
Multi-step reaction with 7 steps
1: ammonium hydroxide / hexane / 3 h / 0 °C
2: Lawessons reagent / dichloromethane / 24 h
3: tetrahydrofuran / 2 h / 20 °C
4: pyridine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C
5: diisobutylaluminium hydride / diethyl ether / 1 h / -78 °C
6: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
7: indium(III) chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; dichloromethane / Heating
With
Lawessons reagent; pyridine; indium(III) chloride; ammonium hydroxide; carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic anhydride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/ejoc.200600671
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisobutylaluminium hydride / diethyl ether / 1 h / -78 °C
2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
3: indium(III) chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; dichloromethane / Heating
With
indium(III) chloride; carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200600671
